Pegylated Gold NP’s Kills Cancer Cells
Nano gold (NP’s) permeate brain tumors.Peg-AuNP’s. It has been proven that the size of the particles has a bearing on the permeation percentage. Gold nanoparticles in 4nm range had the the highest percentage (23.06%). In order to treat brain tumors penetrating the brain microvasculature is the key to treating brain cancers. It is well known that patients with malignant brain tumors. These tumors are surrounded by a porous brain microvasculature allowsAuNP’s to selective target the tumors.
Biomedix pegylated nano particles are excellent candidates for tumor targeting drugs carriers as they permeate the brain microvasculature more effectively than other carriers.
Treating pancreatic cancer cells, it has been reported in several proof-of concept studies, that when the chemotheraputic effect of DOX against pancreatic cancer cells as more then 30 times,while the in vitro anti-tumor efficacy of DOx was 48 times higher when PEG-AuNP,s were actively targeted.
In another in vivo study, it was was demonstrated 100nm gold particles accumulated in human breast cancer tumors and were heated with laser and caused irreversbile tissue damage and no tumor recurrence after 90days.
More importantly, gold nanoparticles have the potential to improve contrast with structural imaging modalities including conventional CT and MRI . CT scanning cannot detect cancer cells as iodine cannot be conjugated to molecular proteins!
Gold nanoparticles are now the “smart particles of the future’
